“When Antidepressants Fail, Dose Increase May Be a Less Effective Response” AND more on Best 5 Wednesday Reads

Hello and welcome to another edition of Best 5 Reads. Let’s start!

1) When Antidepressants Fail, Dose Increase May Be a Less Effective Response

As this and previous research on dose increase strategies have produced inconsistent findings, the researchers recommended clinicians consider other responses to antidepressant treatment failure, at least for selective serotonin reuptake inhibitors.

2) ICD-11 Proposed Criteria Identifies Fewer Cases of PTSD

The findings of a study in Psychological Medicine indicated that the proposed criteria for post-traumatic stress disorder in the 11th Revision of the International Classification of Disease (ICD-11) identified significantly fewer cases than the 10th Revision.

The new revision aims to make post-traumatic stress disorder a more specific diagnosis. Symptoms such as difficulty sleeping, poor concentration, irritability, and inability to recall an important aspect of the traumatic event would no longer be considered criteria for post-traumatic stress disorder. In ICD-11, dissociative flashbacks, hypervigilance, being easily startled, and avoidance of stimuli or memories associated with the event would characterize the disorder.

3) The Long Shadow of the Eugenics Movement

Eugenic ideas were very popular in the United States until World War II. Yet statements in today’s public discourse suggest that they live on.

4) Is the Definition of Autism Too Broad?

Some people say the definition of autism is so broad, everyone’s autistic. Others say the current definition is the best we have. Who’s right? An autistic person’s perspective.

5) Bipolar Disorder in the Perinatal Period: No Consensus on Treatment

Managing bipolar disorder in pregnant and lactating patients is challenging enough, but the lack of consistent guidelines worldwide makes the task more daunting.

Clinicians need to weigh the risks and benefits for individual patients while acknowledging that bipolar disorder relapses occur frequently in the perinatal period.

Thank you for your time and see you tomorrow for more interesting reads.

Best Regards,


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